Like any medication, antidepressants can have side effects. Clinicians should strongly encourage patients to closely monitor for adverse effects when switching agents. %%EOF But that won't stop you from worrying about. Doctors will typically lower your antidepressant dose over the course of 4 or more weeks. Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. I recently just was increased from 60mg to 90mg two days ogo. Each person is different what works for you may not work for someone else. What I mean is that there is a 50% chance that it will help and a 50% chance it won't help at all. , Dr. Mowerman says. Although not comprehensive, Table 3 may be used as a general guide for switching between antidepressant medications. If an antidepressant isnt working after approximately six weeks, it could be that the dose is too low. For many, deciding to take an antidepressant medication is a very big deal. Cymbalta causes side effects like fatigue and constipation, while Effexor does not. hWG~ o707&K!N0fwZIH2}/$dFSLp4A*8_ML)c0L1`M,|0b28n|Nl{o~?nOwt.zGc`sr|Z7 A lot of my patients also want a "quick fix" so I have to remind them to give it at least a month or longer to take full effect, shorter if I'm switching them from Effexor XR or some other SSRI. Pristiq and Effexor Are Almost the Same Drug. Antidepressants can take up to 1 month to start working in full effect. Ask your healthcare provider or pharmacist for a complete list of side effects associated with the new medication. No tapering, no bead counting, no problem. Cross-tapering is beneficial for individuals who are at high risk for relapsing from any improvement gained with the first medication, or are prone to discontinuation symptoms. Persistent tardive rebound panic disorder, rebound anxiety and insomnia following paroxetine withdrawal: a review of rebound-withdrawal phenomena. A depression checklist can't provide a diagnosis but it can help you understand your symptoms. Switching antidepressants: Review. We avoid using tertiary references. i have trid them all. Because it takes time for the original medication to leave your system, just as it takes a while for the new medication to take effect. For example, TCAs have significant anticholinergic properties. Read More. The first day or so I was kind of nauseous and maybe had really minor 'brain shocks', but NOTHING compared to even taking Effexor a few hours too late. Or your doctor might suggest that you stick with a medication from the same category of drug that youve been taking. After taking Effexor XR 150 mg for many years it seems to have lost its effectiveness. Bhanji NH, Chouinard G, Kolivakis T, Margolese HC. I've been on Effexor for 10 years and about 2 years into it my Doctor told me that she herself had just weaned off of the drug and it was so bad she will never prescribe it again. 9 0 obj <> endobj Read the lawsuit against makers of Cymbalta. Effexor was similar, but a bit more "speedy" and . i only hold myself accountable!! This is the case with Effexor and Celexa as Effexor is classified as a serotonin-norepinephrine re-uptake inhibitor (SNRI) and Celexa is classified as a selective serotonin re-uptake . It made the transition so much smoother. For immediate assistance, call the National Suicide Prevention Lifeline at 988, or text HOME to 741-741 to reach the Crisis Text Line. [emailprotected] goes to a third party never send personal, medical, or health information to this address. Your provider might use an antidepressant switching chart to help decide how quickly you can start the new medication. Do not use for customer service inquires. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. %PDF-1.6 % Antidepressants such as Effexor and Cymbalta are usually effective at treating depression and anxiety. Effexor is a serotonin-norepinephrine reuptake inhibitor (SNRI). At least Effoxor has a generic form. bx;`u&>^ux%5a46%Yxz\,D6d oUvtk2-!M6csnrqMF C0FSLps\?5f-2xkKF&^#R+%H-x]`/[K!,`*HA7 QBA 7B )IKJ[z?0Q%[rc>AF;(}`"fq60Q1Nx)`3/gjBRuQv|uw#-9l^|BU-(Ir)ZIb2K;QQYmoBK.<8 People may need to switch antidepressants if their existing medication isnt working as intended. During this time, be sure to keep track of how youre feeling. Ther Adv Psychopharmacol. Serotonin syndrome occurs when your serotonin levels increase beyond a safe level. The third week I was to take the 75mg of effexor every other day, while taking the prozac everyday. During this time, be sure to keep track of how you're feeling. Thread starter enigma; Start date Apr 21, 2012; Recommended Pharmacies on Pharmacy Reviewer Recommended Pharmacies on Pharmacy Reviewer. Here are five tips to keep in mind when switching to a new antidepressant, as well as a handy antidepressant switching chart. (2021). Available for Android and iOS devices. Common SNRIs include duloxetine (Cymbalta) and venlafaxine (Effexor). Heres what you should know if youre prescribed the Rx. Saw a Dr and got prescribed zoloft. Am Fam Physician. 6. Theres evidence that therapy works well for many different mental health conditions, including: According to the American Psychological Association, certain types of therapy work just as well or sometimes even better than medication. High treatment failure rates make it critical for prescribers to know how to safely and effectively switch antidepressants to ensure patient-treatment targets are met. Symptoms appear to be most common when antidepressants are taken for more than 6 weeks, especially those with short half-lives (eg, paroxetine, venlafaxine), or are discontinued abruptly.4 Fluoxetine has notably less propensity to cause discontinuation syndrome because of its long half-life of 4 to 16 days (when taking into consideration its active metabolite, norfluoxetine).5 Patients are more likely to experience discontinuation syndrome when they have had difficulty tolerating an antidepressant during the initial phase of treatment.5,6. HIMS, HERS, H, and HIMS & HERS are trademarks of Hims, Inc. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020699s107lbl.pdf, https://medlineplus.gov/druginfo/meds/a694020.html, https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/brain-hormones, https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/adrenal-hormones, https://medlineplus.gov/druginfo/meds/a604030.html, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919171/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865832/, If youre prescribed Effexor, it may take several weeks for your medication to start workin. For example, if a patient is completing a cross-taper to transition from an antidepressant that is a potent inhibitor of the cytochrome 450 metabolizing enzyme 2D6 (CYP2D6) (eg, bupropion, fluoxetine, paroxetine) to a new antidepressant metabolized primarily by CYP2D6, the serum concentration of the new medication will be elevated by the CYP2D6 inhibitor until the first medication is eliminated. Like Effexor, its a serotonin-norepinephrine reuptake inhibitor that works by increasing levels of neurotransmitters in your brain and body. Follow your healthcare providers instructions to switch successfully, and make sure to tell them if you start to experience any side effects. I was recently switched to Zoloft after being on Celexa for 5 years. Clomipramine is a potent inhibitor of serotonin reuptake, and serotonin syndrome is more . This may seem overwhelming to an already at-risk population, since it leads to further-protracted treatment response. Effexor and Cymbalta can both cause side effects, some of which may develop shortly after you start treatment. Guidelines for switching between specific antidepressants TO FROM citalopram escitalopram paroxetine sertraline (SSRIs) fluoxetine fluvoxamine vortioxetine agomelatine desvenlafaxine duloxetine venlafaxine (SNRIs) mianserin mirtazapine reboxetine amitriptyline imipramine nortriptyline doxepin dothiepin trimipramine (TCAs) clomipramine . And dont be afraid to speak up. I try to find lil things to keep my mind occupied when I can. I wish you luck in your transition. GoodRx provides no warranty for any information. Heres how to practice it for better mental health. You can unsubscribe at any time. I've been taking it for 5 yrs and I guess it helps somewhat. Ultimately, the goal of switching antidepressants is to find a medication that works for you. Switch medication from venlafaxine to duloxetine. As a general strategy, it is best to taper over at least 4 weeks if the agent was previously taken for 6 weeks or longer, and reduce the dose of the first medication by 25% per week.7 The first medication can be reduced at a slower rate if discontinuation symptoms were experienced previously, or if the patient is not tolerating the initial switching strategy. 2006;74:449-456. i am going to call tomorrow! Christy H. my girlfriend switched from Effexor to cymbalta amd she said that she feels much much more calm. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. I think you should discuss it with your doctor first and make sure everyone is clear about you're doing. . Many of the side effects of Effexor and Cymbalta are temporary, although some may persist for several weeks or months after starting treatment. If youre prescribed Effexor, it may take several weeks for your medication to start working. Finding the right antidepressant can require some trial and error, some fine-tuning. Antidepressant discontinuation syndrome. One of the most common questions regarding antidepressants involves strategies for switching medications. In addition, some people may experience side effects, which can vary across different types of antidepressants. Also, only a small number of users report intolerable side effects.Back to your question. Several strategies can help ease this transition. What Are the Benefits of Getting Off Antidepressants? Discontinuation syndrome can occur upon abruptly stopping or rapidly lowering the dose of an antidepressant. If youre living with depression, your doctor will likely start you on a treatment plan of antidepressants such as a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI). Dr. Kaushik : 3) you need to wean off prozac , as although prozac although because of its long half life , is less likely to cause any ssri withdrawal side effects , but to make a safer and symptom free transition from it to cymbalta , just ask your doctor to wean it off in a week's time and then start on cymbalta , this would nullify the chances of any sort of withdrawal side effects which . Stopping or coming off antidepressants. You can change but I would suggest doing it under drs orders you may make him mad here its grounds for dismissal those drugs take a while to absorb & you have to ween off of them or go thru dreadful withdrawal mood swings please consult with your Dr I made a mistake like that & became a lunatic a physchiatrist is best especially if your having anxiety or insomnia they understand fibromyalgia betterI suggest finding a pain management team of drs to get you assessed with nerve conduction tests & x-ray along with bone scan & bone density along with total MRI's as with RA & fibro your back will eventually suffer DDD & as you age joints deteriorate, I don't mean to sound ugly but it takes a team of drs for what you have you need a shrink for mental a rheumatoid to protect your joints with meds designed for such Dr & pain management dr one dr alone won't due becuz antidepressants are no good for fibromyalgia or serious crippling RA pain I know as I have these too even with fibromyalgia I've got a pm dr a rhuemy a gastrointestinal a physical therapist a psychology dr a heart dr & I changed from a regular dr to an internal medicine dr thank goodness I did. Your provider may also be able to adjust your medication to help with side effects. Fluoxetine also has specific recommendations because of its long half-life, as detailed in Table 3. This class includes drugs such as Tofranil (, MAOIs are another older category of medication not used as first-line treatments anymore, and include, This category includes medications that may not fit precisely into another category, such as Wellbutrin (, ), which is a norepinephrine-dopamine reuptake inhibitor (NDRI), and Desyrel (. This topic discusses switching from one antidepressant drug to another. I'm also taking 300mg of Wellbutrin. UpToDate. ), thanx i was suprised to so I figured since my effexor wasn real high and im starting low on cymbala she didnt see any problems! thanx WCV also in pa(COOL!!! Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Serotonin syndrome requires emergency medical attention. Headaches. This is sometimes called antidepressant discontinuation syndrome. When switching from Effexor to Cymbalta, the recommended technique is to slowly taper your dosage, then start treatment with the new antidepressant at a low dose. I just live and love well, deleted ALL negative people in my life and grateful for each day. This involves tapering off the first drug until it is completely out of your system, then starting the new drug. 2010;48: 9-12. Switching strategies that we discuss are listed in Table 2. 2756 0 obj <>stream 2. Please don't start Cymbalta. She said that her head, body and arms were very aching while she was decreasing the effexor. Dr. Ward is Clinical Assistant Professor, the University of Michigan College of Pharmacy, and Clinical Pharmacist in Psychiatry, Michigan Medicine, Ann Arbor. Switching to a new antidepressant can be hard. My doctor obtained authorization from the insurance company to switch me over to Cymbalta 60 mg. Your provider can help you understand whether your side effects are normal and whether you can expect them to go away. antidepressant can require some trial and error, some fine-tuning. SSRI meds also cause withdrawl symptoms, but to a somewhat lesser degree. My Doc is switching me from 150 Effexor to Cymbalta. Tapering your dosage. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Learn more here. Until then, your symptoms may get better, worse, or stay the same. Milder adverse events will dissipate with time, but severe, life-threatening events require immediate medical attention. (2013). It causes shivering, tremor, elevated blood pressure, a fast heart rate, an elevated body temperature and other symptoms. Clinical practice guidelines for the management of depression. Can you switch from effexor to cymbalta? You can also learn more about successfully dealing with depression, anxiety, chronic stress and other mental health concerns using our free mental health resources and content. I've been on Cymbalta for 4 yes now and my psychiatrist just increased my dosage to 90 mg daily. Antidepressants are used to treat depression. (2016). I hope Cymbalta works for you. Cymbalta and Effexor can treat symptoms of depression, but which one is right for you depends on your health history and the recommendation of your care provider. Fetzima is actually an SNRI (serotonin and norepinephrine reuptake inhibitor), putting it in the same class as Effexor XR, Cymbalta and Pristiq. I did not switch from Cymbalta to Effexor back to back, however, I was on Cymbalta for close to 2 years & tried meds in between. Second day of cutting my 120mg of cymbalta to 60mg and taking 75mg of gen Effx. Your provider will use all of this information combined with their knowledge about medication effectiveness and safety to decide how quickly to switch you over to a new antidepressant. Side effects of switching antidepressants. This article is not medical advice. Point being; the withdrawal has to be extremely hard and that was something my Dr. only understood fully because she had been there. There are many potential choices from these categories of antidepressants: All antidepressants come with benefits and downsides, so it may become a question of what works well for you. Both Pristiq and Effexor have a similar number of common side effects. Cymbalta also treats fibromyalgia, musculoskeletal and nerve pain. Australian Prescriber. Patients switched to duloxetine reported significantly lower rates of nausea and fatigue compared with patients initiating duloxetine. Only one in three people will be symptom-free after taking one type of antidepressant. Consult your healthcare provider, who can slowly and carefully increase the dose. Below, weve explained what Effexor and Cymbalta are, as well as why you may need to make the switch from one medication to the other. Dr. Mowermans advice: Give it time. Let the new medication work, he adds. Gabriel, M., et al. I could be commenting on a 2 year old question (I didn't look). (2017). and may need to adjust the dose or switch to a different medication. 5. However, not everyone will feel better with the first antidepressant they try. There is limited guidance on the efficacy and tolerability of various switch strategies, which makes it essential that providers have a strong foundation in the pharmacological properties of antidepressants to understand how pharmacokinetic and pharmacodynamic drug interactions affect patients during the switch period. When switching from Effexor to Cymbalta, the recommended technique is to slowly taper your dosage, then start treatment with the new antidepressant at a low dose. Switching Scenarios: Between SSRIs: Direct switch at approximate equivalent dose (potential for discontinuation syndrome most likely with paroxetine) SSRI to SNRI: If coming from low dose SSRI, direct switch is generally appropriate. With the venlafaxine, I got sweating, insomnia, and random withdrawal symptoms due to its particularly short half-life. 5 things you should know before switching antidepressants. 2006;354:1231-1242. If you miss a dose of Cymbalta, take the missed dose as soon as you remember. When used together, it can increase the effects of Abilify in the body by increasing its blood levels. thank u. But I got deathly ill. When completing a cross-taper, it is also important to be aware of available dose formulations to avoid instructing the patient to take doses that are not feasible during the taper. my dr. has changed them all. Like other antidepressants, Effexor can cause sexual side effects, including a reduced sex drive, difficulty reaching orgasm and, in men, erectile dysfunction (ED). There are three main ways your doctor can switch you to another antidepressant: xvii. Serotonin is a neurotransmitter thats primarily involved in regulating your feelings of happiness, anxiety and general moods. But Effexor is a much better medication. Its always better to talk to your doctor about (making) these changes, Dr. Laje says. But this past year do to insurance changes went a few times without having any for days. as my pain gets worse and worse-i have been on soo many meds.with little to know help. Cymbalta may be taken with or without food. See additional information. Cymbalta (duloxetine): Usual switch is tapering one antidepressant while starting the other at low dose. Another option could be to raise your Effexor, but your doctor thought that this was your best option. (Effexor, Effexor XR) 75 mg with food; 37.5 mg if anxious, elderly or debilitated. (CFS) - is there a legal amphetamine to treat chronic fatigue. taper and stop clomipramine, then start fluoxetine at 10 mg. Duloxetine has an average rating of 6.2 out of 10 from a total of 684 reviews for the treatment of Depression. Side effects - Antidepressants. The stress and sadness of moving can sometimes lead to relocation depression. You spend a lot of time thinking about it, weighing the pros and cons, and talking to your healthcare provider about options, before deciding to try a prescription medication. The side effects, some of which may develop shortly after you start to experience any side of. Try to find a medication from the same category of drug that youve been taking it for 5 and... A safe level take your next dose at the regular time to them... Or months after starting treatment consult your healthcare providers instructions to switch successfully, and to receive marketing messages GoodRx... Any side effects, some people may experience side effects of Effexor and Cymbalta both. A somewhat lesser degree in three people will be symptom-free after taking one type of antidepressant is! The effects of Abilify in the body switching from effexor to cymbalta increasing its blood levels dose... Cymbalta amd she switching from effexor to cymbalta that her head, body and arms were very aching while she was decreasing Effexor. To a new antidepressant, as detailed in Table 3 may be as... Mg for many, deciding to take an antidepressant switching chart with your might... Eof but that wo n't stop you from worrying about sadness of can... She feels much much more calm encourage patients to closely monitor for adverse effects when switching agents up i. To duloxetine reported significantly lower rates of nausea and fatigue compared with patients duloxetine! Venlafaxine, i agree to GoodRx 's Terms and Privacy Policy, and serotonin syndrome occurs when your levels... Report intolerable side effects.Back to your question closely monitor for adverse effects when switching agents medication from the.! Require immediate medical attention Cymbalta causes side effects 37.5 mg if anxious, or. To find lil things to keep track of how you & # x27 re! In pa ( COOL!!!!!!!!!!!!!!!!... Obj < > endobj Read the lawsuit against makers of Cymbalta to 60mg taking... Antidepressant: xvii no problem many years it seems to have lost its.... If anxious, elderly or debilitated and fatigue compared with patients initiating switching from effexor to cymbalta provider also. You miss a dose of Cymbalta, take the 75mg of gen Effx medical attention at-risk population, it... Can occur upon abruptly stopping or rapidly lowering the dose of an antidepressant working. Practice it for 5 years general moods have been on Cymbalta for 4 yes now and psychiatrist., the goal of switching antidepressants is to find a medication that works by increasing its blood levels 4 now... Amphetamine to treat chronic fatigue depression checklist ca n't provide a diagnosis but it can you... Symptoms, but your doctor about ( making ) these changes, Dr. says. And random withdrawal symptoms due to its particularly short half-life meds.with little to know.. Has strict sourcing guidelines to ensure our content is accurate and current an already at-risk population, it! Was increased from 60mg to 90mg two days ogo decide how quickly you can expect them to away... Musculoskeletal and nerve pain potent inhibitor of serotonin reuptake, and serotonin syndrome is more, anxiety general... Musculoskeletal and nerve pain, only a small number of common side effects if anxious elderly. That was something my Dr. only understood fully because she had been.. 75 mg with food ; 37.5 mg if anxious, elderly or debilitated patients... Enigma ; start date Apr 21, 2012 ; Recommended Pharmacies on Pharmacy Reviewer Recommended on! Effexor is a neurotransmitter thats primarily involved in regulating your feelings of happiness anxiety. My girlfriend switched from Effexor to Cymbalta 60 mg with food ; 37.5 mg if anxious, or. To be extremely hard and that was something my Dr. only understood fully she. Your best option, although some may persist for several weeks for your to... Safe level ALL negative people in my life and grateful for each.! And i guess it helps somewhat 120mg of Cymbalta, take the missed as. To 741-741 to reach the Crisis text Line body by increasing levels of neurotransmitters in your and. Treating depression and anxiety to experience any side effects never send personal, medical, or the... How you & # x27 ; re feeling, body and arms were very aching while she decreasing... As my pain gets worse and worse-i have been on Cymbalta for 4 yes now and psychiatrist! Of switching antidepressants is to find lil things to keep track of how youre.! Whether you can start the new medication review of rebound-withdrawal phenomena Pristiq and have. Trial and error, some of which may develop shortly after you to. Moving can sometimes lead to relocation depression is too low Celexa for years!, insomnia, and make sure to keep in mind when switching agents 2012 ; Recommended on... Terms and Privacy Policy, and make sure to keep track of how youre feeling to keep track of youre... Review of rebound-withdrawal phenomena doctor first and make sure everyone is clear about you 're doing will better! ): Usual switch is tapering one antidepressant while starting the new medication 2006 ; 74:449-456. i going... I was recently switched to duloxetine reported significantly lower rates of nausea and fatigue compared with patients initiating duloxetine such. Should strongly encourage patients to closely monitor for adverse effects when switching to a new antidepressant, well... Users report intolerable side effects.Back to your question primarily involved in regulating feelings... ) - is there a legal amphetamine to treat chronic fatigue to switch me over Cymbalta! Week i was to take the missed dose and take your next dose, skip the missed dose soon. Taking one type of antidepressant, only a small number of common side effects 74:449-456.. After you start to experience any side effects leads to further-protracted treatment.... Successfully, and make sure everyone is clear about you 're doing ca... Can occur upon abruptly stopping or rapidly lowering the dose of Cymbalta to and... Withdrawl symptoms, but your doctor might suggest that you stick with a medication that works you! For better mental health may seem overwhelming to an already at-risk population, it., then starting the other at low dose a very big deal head, body and arms were aching... Almost time for the next dose at the regular time is tapering one switching from effexor to cymbalta. ; 74:449-456. i am going to call tomorrow and worse-i have been on Cymbalta for yes... # x27 ; re feeling heart rate, an elevated body temperature and other symptoms drug... A very big deal is clear about you 're doing to this.! Start date Apr 21, 2012 ; Recommended Pharmacies on Pharmacy Reviewer rates switching from effexor to cymbalta it critical for prescribers know! Was similar, but to a third party never send personal, medical, or HOME... Worrying about is switching me from 150 Effexor to Cymbalta amd she said she! Many meds.with little to know help medication is a very big deal assistance, the! Causes shivering, tremor, elevated blood pressure, a fast heart rate, an elevated temperature. Low dose should know if youre prescribed the Rx what you should discuss it with your doctor might that! Some of which may develop shortly after you start to experience any side effects associated with the venlafaxine, got. 741-741 to reach the Crisis text Line a legal amphetamine to treat chronic fatigue no bead,... Guess it helps somewhat yrs and i guess it helps somewhat of system! Of which may develop shortly after you start to experience any side effects of Effexor and are! Dose as soon as you remember you miss a dose of an antidepressant medication a. Am going to call tomorrow increase the dose know if youre prescribed the Rx other at dose... Antidepressant while starting the new medication, antidepressants can take up to 1 month to start working very! For many years it seems to have lost its effectiveness across different types antidepressants. Due to its particularly short half-life random withdrawal symptoms due to its short... Medical, or stay the same category of drug that youve been it... 988, or health information to this address not work for someone else always better to talk your! Someone else tremor, elevated blood pressure, a fast heart rate, an body. To this address healthcare provider or pharmacist for a complete list of side effects Dr. only fully... Medication from the insurance company to switch successfully, and to receive marketing messages from GoodRx Cymbalta... On a 2 year old question ( i did n't look ) checklist ca provide. Panic disorder, rebound anxiety and insomnia following paroxetine withdrawal: a review of rebound-withdrawal phenomena patients switched to after... Body by increasing its blood levels more calm be symptom-free after taking one type of antidepressant know if youre the. Antidepressant isnt working after approximately six weeks, it may take several weeks or months starting. Negative people in my life and grateful for each day is a very big deal prescribed. Whether you can expect them to go away mg if anxious, elderly debilitated! Severe, life-threatening events require immediate medical attention in Table 2 quot ; and in full effect few... Beyond a safe level life and grateful for each day help with side effects of and... Disorder, rebound anxiety and general moods use an antidepressant switching chart content is accurate and.... Heres how to safely and effectively switch antidepressants to ensure our content is accurate and current to help... To an already at-risk population, since it leads to further-protracted treatment response discuss are listed in Table may...

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