If you are worried about this, it is important to talk with your doctor before you start treatment. Stage 4 means that the cancer has spread to one or more other organs. Always tell other doctors, nurses, pharmacists or dentists that youre having this treatment. Back and can add some more Not sure if you read my profile. Again different chemo than you, but the Oxi is the neuropathy and cold culprit. They can slow down your drip if this happens. If you have DPD deficiency, this can affect the treatments that are available for you. Even if going out to get a cup of coffee for a bit. You might want to hurry and get a few pairs of those stretchy knit gloves that are one size fits all. I had it surgically removed on March 22. Whatever cancer throws your way, were right there with you. You might also feel feverish and your eyes may be more sensitive to light. Where I live gets really cold in the winter and when I leave the cancer center after the iv if it's really cold I have to cover my nose and mouth to breath when I'm outside, but that usually only lasts a day or two. You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. It is still possible for the heart to be affected even if these test results are normal. This treatment may make your eyes feel sore, red and itchy (conjunctivitis). You may get sore and red palms of hands and soles of feet. Try not to worry too much and do whatever you can. Based on the gene mutation profile, the patient received the bevacizumab-oxaliplatin regime and then the bevacizumab-capecitabine as maintenance treatment. Capecitabine and lapatinib were given orally at escalating doses, starting at capecitabine 1500 mg/m(2)/day on days 1-14 and lapatinib 1000 mg daily on days 1-21. We help people get through cancer. This treatment can reduce the number of platelets in your blood. I'd come home from chemo with my fingers tingling, but not really painful. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. You might be breathlessand lookpale due to a drop in red blood cells. Were here to provide physical, financial and emotional support. They include: These side effects happen in fewer than 1 in 100 people (less than 1%). They may give the next doses of oxaliplatin over 4 to 6 hours to reduce the chance of throat spasms. The arm I get the iv in is sore for a few days after as well, so I always get it in my left arm because I'm right handed. Capecitabine is an antimetabolite, belonging to the fluoropyrimidine carbamate class. I guess that makes me T3 N1b M0. Red blood cells carry oxygen around the body. Some medicines can affect how this treatment works or be harmful when you are having it. They also depend on what othertreatment you are having. The National Comprehensive Cancer Network (NCCN) has released new guidelines for ampullary adenocarcinoma, a disease accounting for just 0.2% of all gastrointestinal malignancies. In the UK, live vaccines includerubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax. Stay as active as you can for as long as you can. This could be a sign of infection or more rarely lung problems such as asthma, a blood clot in the lung, a collapsed lung (pneumothorax), or changes to the lung tissue, making it less flexible. This treatment may also cause blurry vision. This treatment can cause changes to the lungs. You should contact youradvice line urgently if you think you have an infection. Talk to your doctor or nurse about effective contraception before starting treatment. If cisplatin is substituted by oxaliplatin and 5-FU by . I get the oxaliplatin every 3rd Monday and then take the capecitabine twice a day for two weeks, then one week off before starting again. And today I learned my "copay" for two weeks of capecitabine is just short of $1,100USD. This treatment can cause your blood sugar and sodium levels to go up. For further information about this treatment go to the electronic Medicines Compendium (eMC)website. She still had a brilliant outcome from treatment . If it is something where you can say screw it and deal with it later, that could be easier. If I'm tired I take a nap, but I try to be as active as I can. You may also feel unwell with flu-like symptoms such as a high temperature and joint pain. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. This can cause difficulties with swallowing and breathing. I know I won't put gloves on to get things out of the fridge, so I pull my sleeves down over my hands. Isle of Man company number 4694F. Oxaliplatin can make you more sensitive to the cold. Rarely some people might cough up blood or have unusual bleeding from the vagina. Well, I can't tell you what to do, so let me re-word that. Stir the water with a spoon until the tablets are completely dissolved and then drink it immediately. Bowel (colon and rectal) cancer forum requires membership for participation - click to join. Save these numbers in your phone or keep them somewhere safe. I kept a pair of new,clean gardening gloves in the kitchen specifically for handling cold things and for reaching into the freezer. This can cause symptoms including: Tell your doctor or nurse straight away if you notice any of these symptoms. The results showed great effectiveness of the treatment and the patient remains progression-free and continuous decrease of CA-199 level as of to-date. The difference in my mum was amazing and just gave her some quality of life again . Thats a very annoying side effect. You might have two different strengths of tablets to make up the correct dose. Signs of a severe skin reaction include peeling or blistering of the skin. Your healthcare team will tell you what moisturiserto use. Oxaliplatin is a third-generation platinum compound in which the platinum atom is complexed with a 1.2 diamino-cyclohexane and with an oxalate ligand as a leaving group. Less commonly you might have a dry mouth. This includes vitamins, herbal supplements and over the counter remedies. Your doctor, nurse or pharmacist can tell you more about this. I liked being on Xeloda rather than the 5-FU pump. I am a sports junkie and love baseball. Oh well! Take the drugs exactly as your nurse or pharmacist tells you. The combination of capecitabine and oxaliplatin, with or without bevacizumab, a monoclonal antibody . But it is important that you know about it. It is easier to prevent sickness than to treat it after it has started. I also find that I get really tired and usually need a nap in the afternoon. A blood clot is serious, but it can be treated with drugs that thin the blood (anticoagulants). This can make you more likely to get a mouth or throat infection. FOLFIRI Protocol V1.1. If you feel sleepy, do not drive or use machinery. 5528 Background: Advanced mEOC responds poorly to standard therapy. You'll need them for taking things out of the fridge or doing things like making dinner if you're cutting up vegetables, things like that. I wish you luck as you start your chemo jouney. ChildrenUse and dose must be determined by your doctor. Your nurse usually gives you anti-sickness (anti-emetic) drugs before the chemotherapy. Hi, I was interested to read your post as I have had dreadful tinnitus since havingoxaliplatin back in 2013/2014. If this isn't possible, wash your hands well after changing their nappy. Introduction & Objective: The combination of oxaliplatin and capecitabine has demonstrated its effect against various gastrointestinal cancers. A lot of it may just be luck or makeup, things not in our control, but mindset and determination are also a big part of all of this. Although I mentioned it to the nurse who did my infusions I never mentioned it to the oncologist. Sucking ice chips may sometimes help relieve mouth or throat pain. April 2017 #1. Less common skin problems might include your skin getting dry, peeling, blistering, cracked, and changes in skin colour. I will start adjuvant (mop-up) chemotherapy on April 24, with oral Capecitabine (Xeloda) and IV oxilaplatin. Great! If your skin feels dry, try using an unperfumed moisturising cream every day. Your hospital team may give you anti-diarrhoea drugs to take at home. I had my port-a-cath implanted a day before my first infusion. Very rarely, capecitabine may cause a more serious skin condition. The lab work showed I had Stage 3 cancer with 3 of 27 lymph nodes affected. If you have sex during a course of this treatment, you should use barrier protection such as a condom or dental dam. Ive not heard of oxaliplatin causing tinnitus but Ive had a quick google and it is a known side effect although not one of the more common ones. If you have headaches, tell your doctor. VAT no: 668265007, Coping with the news you have incurable cancer, Spring Picture Festival - Share your Spring. 1-21 Capecitabine 2625mg/m BD PO All patients must have documented DPYD status and capecitabine doses adjusted accordingly prior to commencing treatment as per local practice. The oncologist wasn't convinced the AF was caused by chemo so when I had lung mets surgically removed in 2016 he prescribedcapecitabine as a mop- up treatment. I try not to plan much for the week of iv chemo. Reading questions, answers and feedbacks made me feel very comfortable due to my illness with colon cancer stage 3. If you are very anaemic, you may need a drip to give you extra red blood cells. Aims: To determine the efficacy of the combination of oxaliplatin and capecitabine in patients with advanced colorectal cancer. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniquescan allhelp. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. You may also get mouth ulcers. You are taking steps to ensure your father gets the best treatment. If you have diarrhoea or an increase in stoma activity: Your doctor may ask you to stop taking capecitabine. needing to pass urine (pee) a lot, or discomfort when you pass urine. God bless you on this journey. If the number of red blood cells is low, this is called anaemia. Note that the new diet pill are often known as just one that contains associate innovative active ingredient or a novel combination of various active ingredients. Contact a doctor straight away if you have any of the following symptoms: Read more about treatment for bowel cancer, Find out more about having a DPD deficiency, drop in thenumber ofplatelets in your blood, skin on your hands and feet may become sore, red, or may peel, Read more about how to cope with side effects, Find out more about the COVID-19 vaccine and cancer. It is important to keep hands and feet well moisturised. I agree with the people who are saying not to stay in bed. Abstract. Instructions on how you can make a PDF version of this page using the print function on your browser. For colorectal cancer: Doing gentle exercises each day can keep your energy up. God bless us all troopers!! oxaliplatin and capecitabine (CAPOX) before CRT and TME in pa-tients with poor prognosis rectal cancer in a single-arm phase II trial (EXPERT).30 Patients received four cycles of CAPOX followed by capecitabine CRT, TME, and 12 weeks of adjuvant capecitabine. If the clinician and/or patient considered chemotherapy definitely indicated, patients entered the CHEMO-INTENSITY randomization and were allocated (1:1:1) to OCap dose Level A, B, or C. Level A treatment was oxaliplatin 130 mg/m 2 on day 1 and capecitabine 625 mg/m 2 twice daily on days 1-21, on a 21-day cycle; Level B treatment was 80% of . Other rare skin changes include ulcers, raised areas of skin that may be itchy, being sensitive to sunlight and previously treated areas of skin with radiation can become irritated and inflamed. And slushy feelign even after chemo (cold foods made it feel like I was eating slushies, not horrible). Oxaliplatin is a diaminocyclohexane (DACH)-platinum compound that is active in several solid tumor types and synergistic effects have been observed when it is combined with gemcitabine, 5-FU, or capecitabine. I wear slippers around the house, and a big sweater. If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. You may find it hard to fasten buttons or do other fiddly tasks. At that time I was only working M-W (not related to chemo). The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine . It can help to: Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. Your cancer doctor or GP can tell you more about live and inactivated vaccinations. Sometimes exhausted to the bone, other times not so bad. If you feel unwell or need advice, you can call them at any time of the day or night. You take capecitabine tablets in the morning. The risk of this happening is very low (less than 1 in 100 or 1%). You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. It is a treatment for bowel cancer (colorectal cancer). Actually, I feel pretty good. Don't push yourself, rest when you start to feel tired and ask others for help. It is normal. INTRODUCTION; REGIMENS. This will have a calming effect and help your breathing return to normal. You must take tablets according to the instructions your doctor or pharmacist gives you. We cannot list every side effect for this treatment. This is called a blood transfusion. Your nurse or doctor will discuss your treatment plan with you. Toxic effects of capecitabine and fluorouracil were similar. It is important to take them exactly as your nurse or pharmacist explains. They include: Numbness or tingling in fingers or toesis often temporary and can improve after youfinish treatment. Results: Ten patients received treatment per study protocol. tiny red or purple spots on the skin that may look like a rash. Tell them if the pain gets worse or does not get better. Good luck with the rest of your treatment. This is to help lower your risk of getting COVID-19 while having cancer treatment and until your immune system recovers from treatment. blood in your urine (pee) or stools (poo). Any changes to your skin are usually temporary and improve when treatment finishes. After your treatment is over, most side effects start to improve. Oxaliplatin & Capecitabine. Its only temporary but can feel quite frightening. Your doctor may give you anti diarrhoea medicine to take home with you after treatment. I can't comment on the treatment, as I think I had about every side effect in the book, so you don't need to hear from me, but there are several folks here on the forum, who did very well Oxaliplatin and Xeloda (I was on the Oxi and 5FU infusion) and I'm sure they will be happy to help you along your way. If you have an intolerance to lactose, contact your doctor before taking this medicine. Call freephone 9 to 5 Monday to Friday or email us. Try different foods to find out what tastes best to you. The capecitabine doesn't seem too bad. And yes, I would be walking around the stadium with a chemo bottle under my shirt. Help to Overcome Problems Effectively. Try to pace yourself and plan your day so you have time to rest. sometime have programs to help with the cost. Always tell your doctor, nurse or pharmacist about any side effects you have. Chemotherapy is anti cancer drug treatment. Now I know I have to drink only warm or hot water for a few days after the iv. Most people get it along with Xeloda. Talk to your healthcare team before you stop taking or miss a dose of a cancer drug. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . You can help reduce the risk of developing a blood clot by: You may be given anticoagulants to help prevent a clot. You may have tests to see how well your heart is working. The cancer center I go to changed the way they do it and now I get it over 4 hours and that's much better. Ask them if you can take paracetamol to help loweryour temperature. In this case, dissolve the tablets in a 200ml glass of warm water. What's going on near you? Use of this online service is subject to the disclaimer and the terms and conditions. I'm on Xeloda right now and have been on it for a week and have had no side effects at all. They check your levels of blood cells and other substances in the blood. Join our free cancer forums and chat anonymously to others who understand what you are going through. Cancer drugs can interact with some other medicines and herbal products. It is important to get any infection treated as soon as possible. You may have ringing in the ears. I liked Gold Bond Aloe, but everyone has their favorite. Or ifyou can't drink to replace the lost fluid. I love to be active so I will try to stay out of bed as much as possible. your temperature goes over 37.5C (99.5F), you suddenly feel unwell, even with a normal temperature. Call your doctor or the 24-hour number the hospital has given you. FOLFIRNOX can be used in different ways. Ask your doctor or pharmacisthow long you should avoid live vaccinations. Some cancer treatments can cause severe side effects. It's been quite a while since I had chemo, but I think it was oxaliplatin that, caused the electrical shock when touching something cold. Find out about the emotional, physical and practical effects of cancer and how to manage them. You should take the right dose, no moreor less. Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). Public Health England K - References. Less commonly you might get pain from other areas of the body such as your joints, bones, limbs, or chest. It is important to use contraception during your treatment and for a while after treatment finishes. Talk to your doctor if you are worried about this. There, that sounded less commanding. Rarely, these may be life-threatening. Your nurse will give you telephone numbers for the hospital. Get someone else to changetheir nappies during this time if you can. Tell your doctor or nurse if you have ulcers. Your doctor can give you drugs to help control some side effects. I had a touch of each possible side effect, but limited. Encorafenib and Cetuximab Metastatic Colorectal Cancer Protocol V1.1. I hope so! They will talk to you about your blood results and ask you how you have been feeling. Dont breastfeed during this treatment and for 2 weeks after your final treatment. I truly can relate with your feelings along with the experience of the financial issue. You may have nosebleeds or bleeding gums after brushing your teeth. Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. In the secondary analysis, overall survival was longer with EOX than with ECF, with a hazard ratio for death of 0.80 in the EOX group (95% CI, 0.66 to 0.97; P=0.02). Before starting treatment with capecitabine you have a blood test to check levels of an enzyme called dihydropyrimidine dehydrogenase (DPD). To add to what JJ said, if you have issues finding gloves, I actually used some gloves I got at Lowes. The lab work showed I had Stage 3 cancer with 3 of 27 lymph nodes affected. A number of large-scale clinical trials have demonstrated that using a combination of oxaliplatin and fluoropyrimidines as an adjuvant chemotherapy for stage II/III colon cancer improved the prognosis. 1. This means you have the drugs and then a rest to allow your body to recover. On the other hand, Epirubicin, Cisplatin plus continuous infusion of 5-FU is widely used as a palliative regimen in patients with gastric cancer. If you need to talk, we'll listen. It usually gets better after treatment ends. A company limited by guarantee, registered in England and Wales company number 2400969. If you click my profile I have some details. XELOX and CAPOX are different names for the same combination of chemotherapy drugs. This completes your first cycle of XELOX. Mouth sores and ulcerscan be painful. I also hadAF (atrial fibrillation) in 2013 which I believe was caused by the chemo. Infections can sometimes be life threatening. It can cause damage. 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