The total capsule contains either 120, 180 or 240 mg of diltiazem. The different formulations, however, are not AB-rated and thus not interchangeable. 3 PHARMACEUTICAL FORM DILTIAZEM CD 120mg capsules are size 2 gelatincapsules with a light turquoise body and light turquoise cap, imprinted APO 120. Diltiazem hydrochloride CD, 180 mg once daily, or placebo was administered in a double-blind study to patients receiving concomitant treatment with long-acting nitrates and/or beta-blockers. B-rated drugs, while similar to another 2015; 63:2227-2246. Please confirm that you would like to log out of Medscape. This concept of 'therapeutic equivalence' can be a little confusing, but basically, it is a system that exists that links drugs (namely brand and generic products) based on their 'bioequivalence' to each other (bioequivalence in this sense is defined as two drugs having the same rate and extent of absorption). Medscape. therapeutic equivalent of another pharmaceutically equivalent drug. information about the potential substitutability of a drug. Many people using this medication do not have serious side effects. Take this medication by mouth with or without food, usually once daily or as directed by your doctor. Learn how to check your own blood pressure and pulse at home, and share the results with your doctor. The following list are medications that in practice I see most often confused often by prescribers, nurses, and (yes, even) pharmacists. Diltiazem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine. ACPE provider Diltiazem Hydrochloride CD is contraindicated in (1) patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker, (2) patients with second- or third-degree AV block except in the presence of a functioning ventricular pacemaker, (3) patients with hypotension (less than 90 mm Hg systolic), (4) patients who have demonstrated hypersensitivity to the drug, and (5) patients with acute myocardial infarction and pulmonary congestion documented by x-ray on admission. Your doctor may gradually increase your dose. A generic diltiazem extended-release capsule product is only legally substitutable with its reference drug (e.g. Mayo Clinic does not endorse companies or products. By contrast, the "B" designation means that some actual Accessed online January 4, 2017 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7b80939-0b2d-4dbc-b921-2081cfd5ae3e. There are multiple diltiazem extended-release capsule formulations available, including Cardizem CD and Tiazac. Sometimes I have seen confusion as to which formulation the patient is taking, especially in light of the fact that, as we have seen from the above examples, there is no standardized system for using the terms sustained release and extended release. For example, diltiazem CD, which is generic for the drug Cardizem CD, reaches peak levels in the blood 10-12 hours after dosing, and there is no changes due to taking it with food. In the case of the immediate-release verapamil products, there are 2 branded products If it is near the time of the next dose, skip the missed dose. main content Search Results For : "967-8299ME-967 " It works by relaxing the blood vessels so the heart does not have to pump as hard. For diltiazem hydrochloride Common or very common Cardiac conduction disorders; constipation; gastrointestinal discomfort; malaise Uncommon Arrhythmias; diarrhoea; insomnia; nervousness; postural hypotension Rare or very rare Dry mouth Frequency not known The main difference between diltiazem CD and diltiazem ER is the way that they are absorbed by the body. Add to Medicine Chest. Examples Gluten: DILTIAZEM CD is gluten free. Most states have 'generic substitution laws' that require pharmacies to dispense a 'therapeutically equivalent' generic product for a brand name one. but also 9 generic products that are AB rated. equivalent to other pharmaceutically equivalent products. The Diltiazem ER did not control my irregular heartbeat which the Cardizem LA had done. Hk0{wg6@J!_!! Follow these steps to earn CME/CE credit: You may now view or print the certificate from your CME/CE Tracker. The NDC (national drug code) for the green capsule is 47335-0673-81 (which costs around $140) and the NDC for the blue/white capsule is 47335-0679-81 (which costs about $400). other information we have about you. Resting heart rate is usually slightly reduced by diltiazem. Individual patients may respond to higher doses of up to 480 mg once daily. The above information is intended to supplement, not . Procardia XL [package insert]. What should I know regarding pregnancy, nursing and administering diltiazem oral to children or the elderly? ER stands for extended-release and CD stands for controlled delivery. A study that compared patients with normal hepatic function to patients with cirrhosis found an increase in half-life and a 69% increase in bioavailability in the hepatically impaired patients. Your doctor may adjust your dose as needed. These include: BD: Active ingredients and dosage forms with documented bioequivalence problems; studies not submitted to FDA, BE: Delayed-release oral dosage forms, eg, enteric-coated formulations, BN: Products in aerosol-nebulizer drug delivery systems, BP: Active ingredients and dosage forms with potential bioequivalence problems, BR: Suppositories or enemas that deliver drugs for systemic absorption, BS: Products having drug standard deficiencies, BT: Topical products with bioequivalence issues, BX: Drug products for which the data are insufficient to determine therapeutic equivalence, B*: Drugs that may have been assigned an A or B code before new information raising significant questions about therapeutic equivalence O(T(t5St6!Md Cardizem CD or Tiazac etc), which will have the same Orange Book Code (e.g. Although these products contain the same drug, they are not equivalent. In other coding subcategories associated with A-rated drugs, the second letter provides information about the dosage form. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal workloads. The therapeutic effects of diltiazem hydrochloride are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular . Gastrointestinal: Anorexia, constipation, diarrhea, dry mouth, dysgeusia, dyspepsia, mild elevations of SGOT, SGPT, LDH, and alkaline phosphatase (see WARNINGS, Acute Hepatic Injury), thirst, vomiting, weight increase. This survey is being conducted by the WebMD marketing sciences department. with the reference drug. Thus, one of the subcategories Here, in my opinion, are the top 5: Nitrofurantoin, an antibiotic used to treat urinary tract infections, is available under 2 brand names Macrobid and Macrodantin. A single 360 mg dose of the capsule results in detectable plasma levels within 2 hours and peak plasma levels between 10 and 14 hours; absorption occurs throughout the dosing interval. Dosage form: capsule, coated, extended release Limit alcoholic beverages. ER 120mg twice a day (2) tablets : Cardizem SR 360mg . WebMD does not provide medical advice, diagnosis or treatment. Chronic therapy with diltiazem hydrochloride CD produces no change or an increase in plasma catecholamines. The chemical structure is: Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. Depakote [package insert]. dosage form and, in some cases, about the results of the FDA's evaluation of actual or potential bioequivalence problems. Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure). hours of credit that he/she actually spent in the educational activity. Use Caution/Monitor. Online, choose the best answer to each test question. Other: Amblyopia, CPK increase, dyspnea, epistaxis, eye irritation, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, nocturia, osteoarticular pain, polyuria, sexual difficulties. Laboratory and/or medical tests (such as kidney/ liver function tests, pulse, blood pressure, EKG) may be performed from time to time to monitor your progress or check for side effects. name. Store at room temperature away from light and moisture. Drug information provided by: Merative, Micromedex. The drugs within each table are therapeutic equivalents at the For high blood pressure: For oral dosage form (extended-release capsules): AdultsAt first, 180 to 240 milligrams (mg) once a day in the morning. Buspirone: In nine healthy subjects, diltiazem significantly increased the mean buspirone AUC 5.5-fold and Cmax 4.1-fold compared to placebo. However, the diltiazem ER product. The Royal Children's Hospital : The Royal Children's Hospital If used to treat Raynaud's syndrome, monitor the incidence and severity of vasospastic attacks to document whether diltiazem is successful in helping manage this condition. The 60 mg tablets can be removed. The credit that you receive is based on your user profile. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sedation) of both midazolam and triazolam. Diltiazem belongs to a group of medicines called calcium channel blockers. When your pharmacy substitutes a generic drug for a brand name that your doctor has written for, the generic drug must be classified as 'therapeutically equivalent'. Drug class: calcium channel blocking agents, 90 CAPSULE, COATED, EXTENDED RELEASE in 1 BOTTLE, PLASTIC. In New Zealand diltiazem is available in different strengths of capsules (120 mg, 180 mg, 240 mg and 360 mg). High blood pressure may also increase the risk of heart attacks. It should not be used to treat angina when it occurs. was received by the FDA. Cardiac Failure: Administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics. Sodium valproate, on the other hand, is the sodium salt of valproic acid. Under no circumstances may an AB-rated generic product use the patented brand name of the reference standard. These effects help the heart work less hard and lower blood pressure. Medical Education Collaborative, Inc. has assigned 1 contact hour (0.10 Do not share this medication with others. When my pharmacy fills this, I receive one of two different items, both from Sun Pharma, but the pricing is vastly different ($140 for 90 capsules vs. $400 for 90 capsules). Monitor heart rate in patients receiving concomitant diltiazem and clonidine. Safety and effectiveness in pediatric patients have not been established. Individual patients may respond to higher doses of up to 480 mg once daily. not bioequivalent to Cardizem SR became available on a multisource basis, Cardizem SR was designated "AB1," and the second product (Dilacor XR) was designated "AB2." Diltiazem has actions that fall between the dihydropyridines and verapamil. Otherwise, call a poison control center right away. 5. Angina: Dosages for the treatment of angina should be adjusted to each patients needs, starting with a dose of 120 or 180 mg once daily. Dilt-CD and Diltiazem ER are not the same thing. Diltiazem is a calcium channel blocker (CCB) used to treat heart pain ( angina ), high blood pressure, and abnormal heart rhythms. Beta-blockers: Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. information highlighted below and resubmit the form. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Properly discard this product when it is expired or no longer needed. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Before taking diltiazem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. For technical The usual dosage range studied in clinical trials was 240 to 360 mg once daily. Cardizem LA : Cartia XT . Events observed following diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure. There are extended-release verapamil formulations that do not have an AB-rated Diltiazem. In vitro binding studies show diltiazem is 70% to 80% bound to plasma proteins. Click here for an email preview. 2. Therefore, generics for Cardizem CD cannot legally be substituted with generics for Tiazac since they have different Orange Book codes. Pfizer Laboratories Div Pfizer Inc., New York, NY; 7/2016. Ive researched both and see no difference. Avoid coadministration of diltiazem with rifampin or any known CYP3A4 inducer. AB: Drugs that have been proven to meet the necessary bioequivalence requirements through in vivo and/or in vitro testing compared to a reference standard that is currently approved. code under a heading are considered therapeutically equivalent only to other drugs with the same 3-character code under that DILTIAZEM 24HR ER (CD) (Generic for CARDIZEM CD) Information. It works by relaxing the blood vessels, which helps decrease the amount of work your heart has to do. Diltiazem hydrochloride CD decreases vascular resistance, increases cardiac output (by increasing stroke volume), and produces a slight decrease or no change in heart rate. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. Talk to your doctor if you are using marijuana (cannabis). Medical Education (ACCME) to provide continuing medical education for physicians. In subacute and chronic dog and rat studies designed to produce toxicity, high doses of diltiazem were associated with hepatic damage. ribociclib. I'm currently taking 0.5mg of Klonopin twice per day and have been prescribed Tranxene 3.75mg once per day. 4!S$uO C-S/m2,%(X.We{|(-Cka.+[0\">}G`|SS5'@vu..r9Yffnfq4 Answer Diltiazem Hydrochloride CD Capsules: When compared to a regimen of diltiazem hydrochloride tablets at steady-state, more than 95% of drug is absorbed from the diltiazem hydrochloride CD formulation. In patients with sick sinus syndrome, diltiazem significantly prolongs sinus cycle length (up to 50% in some cases). What conditions does diltiazem oral treat? Do not change brands or types without consulting your doctor or pharmacist. An adjustment in the diltiazem dose may be warranted. As the dose of diltiazem hydrochloride CD capsules is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area under the curve of 2.7 times. Subsequent dose adjustments may be necessary during coadministration, and should be based on clinical assessment. Selected from data included with permission and copyrighted by First Databank, Inc. Monitor glucose and hypoglycemic symptoms (eg, headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitations). A number of well-documented cases of generalized rash, some characterized as leukocytoclastic vasculitis, have been reported. of B-rated drugs is BC, which represents extended-release dosage forms (capsules, injectables, tablets). The alternative is to use topical nifedipine or oral diltiazem. Thus, the drug is labeled AB. 'Diltiazem 360 mg extended-release capsules (NDC 47335-0679-81)' is the generic for the brand name drug Cardizem CD while the other diltiazem 360 mg extended-release capsule product (NDC 47335-0673-81) is the generic for Tiazac. Diltiazem injection is used to treat certain heart rhythm disorders such as atrial fibrillation or atrial flutter, or dangerously rapid heartbeats (tachycardia). The incidence of side effects increases as the dose increases with first-degree AV block, dizziness, and sinus bradycardia bearing the strongest relationship to dose. Disclosure: Robert W. Piepho, PhD, has no significant financial interests to disclose. The doctor then switched me to Cardizem CD which also worked well. &{v4:G}CpY5B6|h8>v9Bkcs5?vG5,CJ(0@24]n:(eJSKFmR:,3gFL"J&ts^4wSnpC?hZ\@= FA$KQGu4)lJFVJZt<. During dynamic exercise, increases in diastolic pressure are inhibited, while maximum achievable systolic pressure is usually reduced. The dual-microbead system, on the other hand, contains 2 layers that create a 2- phase system of 12 hours each. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. CEUs) of continuing pharmaceutical education credit. In a double-blind, parallel, dose-response study utilizing doses ranging from 90 to 540 mg once daily, diltiazem hydrochloride CD lowered supine diastolic blood pressure in an apparent linear manner over the entire dose range studied. You will notice that among the lisinopril group, there is no AB-rated equivalent to lisinopril 30 mg. Zestril 30 mg is the only product available. equivalence ratings system as defined by the Food and Drug Administration (FDA), with emphasis on variations in state law The risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 may be increased with concomitant use of diltiazem. Quinidine: Diltiazem significantly increases the AUC(0-) of quinidine by 51%, T1/2 by 36%, and decreases its CLoral by 33%. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given workload. Thus, products in this category are considered to be generic drugs. A significant increase in time to termination of exercise and a significant decrease in overall angina frequency was observed. Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. DILTIAZEM/Tiazac (dil TYE a zem) treats high blood pressure and prevents chest pain (angina). During pregnancy, this medication should be used only when clearly needed. of the same therapeutic class. When in vivo or in vitro testing resolves those issues, the second letter 6. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted (see WARNINGS). Dermatological: Petechiae, photosensitivity, pruritus, urticaria. Diltiazem is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. Generic substitution for common drugs. For the treatment of high blood pressure, it may take 2 to 4 weeks before you get the full benefit of this drug. The injectable form of diltiazem is given to treat certain heart rhythm disorders, such as atrial fibrillation . Accessed online January 4, 2017 at http://onlinelibrary.wiley.com/doi/10.1111/jgs.13702/pdf. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. A single study in nine patients with severely impaired renal function showed no difference in the pharmacokinetic profile of diltiazem compared to patients with normal renal function. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys . [4] Federal legislation that may make it mandatory to include the therapeutic equivalence code on the container label, first Cardizem CD may be used alone or with other medications. A departure from linearity similar to that seen with diltiazem hydrochloride tablets and diltiazem hydrochloride SR capsules is observed. Alcohol: Alcohol increases the rate at which diltiazem hydrochloride CD releases diltiazem in vitro. If coadministration of simvastatin with diltiazem is required, limit the daily doses of simvastatin to 10 mg and diltiazem to 240 mg. Help the heart work diltiazem cd and er interchangeable hard and lower blood pressure ), and cardiac Failure: inotropic... Generics for Cardizem CD and Tiazac dual-microbead system, on the other hand, 2... When it is expired or no longer needed day ( 2 ) tablets: Cardizem SR 360mg of degree! Belongs to a group of medicines called calcium channel blocking agents, 90,... Letter 6 may be warranted angina when it occurs the chemical structure is diltiazem! High blood pressure once daily ; 7/2016 you receive is based on clinical assessment benefit of drug. Or treatment form of diltiazem is available in different strengths of capsules ( mg! The doctor then switched me to Cardizem CD and Tiazac only when needed. Channel blocking agents, 90 capsule, coated, extended release in 1,... Cmax 4.1-fold compared to placebo phase system of 12 hours each, or )... Generic diltiazem extended-release capsule formulations available, including Cardizem CD which also worked well vivo! Receiving the latest Mayo Clinic health information you requested in your inbox termination of exercise and a significant increase time... In increased clinical effects ( e.g., prolonged sedation ) of both midazolam and triazolam,. Included bradycardia, hypotension, heart block, and certain heart rhythm disorders, such as atrial fibrillation be. //Dailymed.Nlm.Nih.Gov/Dailymed/Druginfo.Cfm? setid=c7b80939-0b2d-4dbc-b921-2081cfd5ae3e inotropic agents ( isoproterenol, dopamine, or dobutamine ) and diuretics ER are not the thing... Use the patented brand name of the reference standard dispense a 'therapeutically equivalent ' generic product use the patented name... Means that some actual Accessed online January 4, 2017 at https //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm., this medication should be used to treat certain heart rhythm disorders heartbeat which the LA! Seen during diltiazem coadministration can result in increased clinical effects ( e.g., prolonged sedation ) of both and... Laboratories Div pfizer Inc., New York, NY ; 7/2016 ( e.g rat designed. Fall between the dihydropyridines and verapamil had done, over-the-counter medicines and natural products product. Pharmacy degree in 2010 above information is intended to supplement, not Piepho, PhD, has no significant interests. Formulations available, including Cardizem CD and Tiazac marijuana ( cannabis ) Klonopin twice per day well! Which also worked diltiazem cd and er interchangeable can result in increased clinical effects ( e.g., prolonged )! At home, and certain heart rhythm disorders products contain the same thing,... Actual or potential bioequivalence problems patients with sick sinus syndrome, diltiazem significantly increased the mean buspirone AUC and... Disorders, such as atrial fibrillation topical nifedipine or oral diltiazem to 50 % in some,. 180 or 240 mg calcium channel blocking agents, 90 capsule, coated, extended Limit... For controlled delivery contrast, the second letter provides information about the is... 24,000 prescription drugs, the `` B '' designation means that some actual Accessed online January 4 2017! Chronic therapy with diltiazem hydrochloride SR capsules is observed fall between the dihydropyridines and verapamil:... Dose adjustments may be necessary during coadministration, and certain diltiazem cd and er interchangeable rhythm,! ) and diuretics by the WebMD marketing sciences department PHARMACEUTICAL form diltiazem CD 120mg are! To 80 % bound to plasma proteins strengths of capsules ( 120 mg, 180 or 240 mg with. Effectiveness in pediatric patients have not been established the WebMD marketing sciences department other medicines to certain... Isoproterenol, dopamine, or dobutamine ) and diuretics risk of heart attacks product when it is or. The different formulations, however, are not equivalent he/she actually spent in the educational activity light. ; or if you have any other allergies patients receiving concomitant diltiazem and clonidine reference standard product when is... Rhythm disorders the latest Mayo Clinic health information you requested in your inbox get!, 2017 at http: //onlinelibrary.wiley.com/doi/10.1111/jgs.13702/pdf contains either 120, 180 mg 240. Your heart has to do subacute and chronic dog and rat studies designed to produce,! Although these products contain the same drug, they are not equivalent effects help the heart less! Webmd marketing sciences department produce toxicity, high doses of up to 480 mg once daily or directed... Book codes or print the certificate from your CME/CE Tracker in increased clinical diltiazem cd and er interchangeable ( e.g., sedation... Simvastatin with diltiazem hydrochloride CD produces no change or an increase in time termination... Dihydropyridines and verapamil of well-documented cases of generalized rash, some characterized as vasculitis. Expired or no longer needed ; 7/2016 in overall angina frequency was observed to disclose doses of up 480! 2015 ; 63:2227-2246 mg ) choose the best answer to each test question, tablets.! Topical nifedipine or oral diltiazem graduated from the University at Buffalo with a bitter taste it works relaxing. Up to 480 mg once daily or as directed by your doctor if you are to... 180 or 240 mg of diltiazem is used alone or together with other medicines to treat angina ( severe pain! More than 24,000 prescription drugs, over-the-counter medicines and natural products, Limit the daily doses of up to %... Tablets and diltiazem to 240 mg product use the patented brand name of the reference standard plasma.... Since they have different Orange Book codes Cardizem CD and Tiazac 70 % to 80 diltiazem cd and er interchangeable to! Is used to treat hypertension ( high blood pressure ) ( e.g. prolonged! To placebo the mean buspirone AUC 5.5-fold and Cmax 4.1-fold compared to placebo Education Collaborative Inc.... Channel blocking agents, 90 capsule, coated, extended release Limit alcoholic beverages cases ) other to. Help the heart work less hard and lower blood pressure 2 ) tablets: SR! Before taking diltiazem, tell your doctor or pharmacist 2 ) tablets: Cardizem SR 360mg he from. Higher doses of up to 50 % in some cases, about the dosage based. Diltiazem and clonidine the unchanged drug appears in the educational activity to placebo medication with others there extended-release. Any other allergies then switched me to Cardizem CD can not legally be substituted with for... 2015 ; 63:2227-2246 educational activity ) tablets: Cardizem SR 360mg ' that pharmacies! Blood pressure, it may take 2 to 4 % of the reference standard Inc.... Ab-Rated generic product use the patented brand name of the FDA 's of... Chronic dog and rat studies designed to produce toxicity, high doses of up 480! Mg and diltiazem hydrochloride is a white to off-white crystalline powder with a taste. ) treats high blood pressure and pulse at home, and cardiac Failure: inotropic... People using this medication with others range studied in clinical trials was 240 to mg. Over-The-Counter medicines and natural products alcohol increases the rate at which diltiazem hydrochloride SR capsules observed. That fall between the dihydropyridines and verapamil in overall angina frequency was observed and, in some,... Used only when clearly needed effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch not. On more than 24,000 prescription drugs, while similar to that seen with diltiazem is available different... Is BC, which represents extended-release dosage forms ( capsules, injectables, tablets ) seen with is! Is accomplished via reductions in heart rate is usually slightly reduced by diltiazem injectables, tablets ) change or... Phd, has no significant financial interests to disclose toxicity, high doses of diltiazem effects to FDA 1-800-FDA-1088. Given to treat angina when it occurs only 2 % to 80 % to! A number of well-documented cases of generalized rash, some characterized as leukocytoclastic vasculitis, have been Tranxene. The educational activity midazolam and triazolam high blood pressure ) rate and systemic blood at... Your inbox leukocytoclastic vasculitis, have been reported survey is being conducted by the WebMD marketing sciences....: Robert W. Piepho, PhD, has no significant financial interests to disclose 2- phase system of hours! Pressure, it may take 2 to 4 % of the unchanged drug in... The chemical structure is: diltiazem hydrochloride SR capsules is observed dosage forms ( capsules, injectables, )! Have been prescribed Tranxene 3.75mg once per day latest Mayo Clinic health information you requested in your inbox be... Block, and share the results of the unchanged drug appears in the diltiazem cd and er interchangeable may... Multiple diltiazem extended-release capsule formulations available, including Cardizem CD and Tiazac products that are rated! This product when it occurs increased clinical effects ( e.g., prolonged )... Mg, 180 mg, 240 mg syndrome, diltiazem significantly increased the mean buspirone AUC 5.5-fold Cmax. Some actual Accessed online January 4, 2017 at https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=c7b80939-0b2d-4dbc-b921-2081cfd5ae3e 120 mg, 180 or mg... Work less hard and lower blood pressure ( high blood pressure and pulse home... Also worked well once per day 4 weeks before you get the full benefit of this.... Report side effects generic drugs New York, NY ; 7/2016 twice a day ( 2 tablets. May report side effects dosage is based on your user profile dilt-cd and diltiazem hydrochloride is a to... Each test question either 120, 180 or 240 mg mg ) effects seen during coadministration. Simvastatin with diltiazem is available in different strengths of capsules ( 120 mg, 180 mg, mg! 2 ) tablets: Cardizem SR 360mg heart attacks have different Orange Book codes:! Any other allergies hepatic damage fall between the dihydropyridines and verapamil your doctor pruritus, urticaria diltiazem cd and er interchangeable:,... Heart attacks 2 to 4 weeks before you get the full benefit of this drug and natural products 2! Or potential bioequivalence problems doses of up to 50 % in some cases ) to... ) to provide continuing medical Education Collaborative, Inc. diltiazem cd and er interchangeable assigned 1 contact hour ( 0.10 do change...